Best Medicinal Mushroom Products: Top Mushroom Supplement Pills & Powders

The popularity of medical mushrooms has seen a massive upward trajectory due to the numerous medicinal benefits.

With every day that dawns, scientists continue to make massive advancements on the psilocybin benefits, making more and more consumers interested in trying out the revolutionary supplements. In the wake of the modern-day, it is much easier to obtain medicinal mushrooms and their supplements on different online platforms.

However, the majority of the mushroom supplements you will find across various platforms do not contain psilocybin as the ingredient is controlled. On the contrary, many mushroom supplements are made up of different mushroom strains with proven medicinal value.

Always be on the lookout when purchasing medicinal mushrooms and supplements because there are many dubious sellers out there. Our website offers a wide range of choices, as we have selected the best medicinal formulas.

The Best Medicinal Mushroom Supplements in 2021

Many online buyers have limited to no access to privileged information about the quality and wellness of mushroom supplements. For that reason, our team has made it easier for you. Our team has thoroughly scrutinized lab reports, peer-reviewed various products, and compared the top-ranking mushroom supplements available across multiple online platforms. Every product that makes it on our list has been thoroughly vetted and is worth your curiosity.

Below is a list of the top-ranking mushroom supplements to look out for:

  • Onnit Shroom Tech SPORT
  • Four Sigmatic
  • Real Mushrooms
  • Mushroom Defense
  • Organixx 7M+
  • Pure Essence MyPure Lion’s Mane
  • The Genius Brand Genius Mushrooms
  • Mushroom Revival
  • Earth Nutri Performance Energy + Focus
  • FreshCap
  • VidaCap
  • Shroomy
  • Ceremony Mushrooms
  • GundryMD Mushroom Vitality
  • Circadian Wellness
  • MycoPhyto Complex
  • Goldmine Supershroom Powder
  • Magic Mushroom
  • Brain Forza Organic Lion’s Mushroom
  • VitaPost Immune Support
  • Spore
  • Vital Plan Adaptogen Recovery
  • The Drug Store Adaptogenic Mushrooms
  • Botany Cordyceps Militaris Extract
  • Plant People WonderDay
  • 5 Mushrooms Reserve Blend
  • MindHoney
  • Brain Boost
  • Onnit Shroom Tech Sports

Onnit Shroom Tech SPORT


Onnit is a household name in the mushroom supplements space. The supplement is a well-known brand influenced mainly by Joe Rogan and sells Shroom Tech SPORT as a daily energy supplement. According to the manufacturer, taking the daily pill of Shroom Tech SPORT boosts energy levels.

Onnit Shroom Tech SPORT is one of the supplements we recommend because it is one of the few mushroom formulas guaranteed by substantial clinical trials. The Onnit company has made massive advancements into conducting clinical trials on Shroom Tech SPORT and other supplements that sell under its brand. On one particular test, Shroom Tech Sport saw an increased number of bench press reps by over 10%, a 7% increase in squat reps, while cardio performance recorded highs of 12%.

Shroom Tech SPORT equips you with natural plant-based benefits, vitamin B12, and a mushroom complex that boosts your energy and offers massive benefits to your body. Every capsule of the top supplement contains 1.2g of cordyceps and 930mg of aphrodisiac blends of ashwagandha, Rhodiola, astragalus root extracts, and green tea extracts, creating a synergetic combination to create maximum benefits.

Four Sigmatic


You will notice that Four Sigmatic is a familiar supplement because of the numerous publications due to its vegan proteins and coffees. TIME and Goop Women’s Health are just but a few of the publications that have covered the benefits of this sought-after mushroom supplement. The supplement offers the synergy of mushroom extracts and other plant extracts.

In another light, Four Sigmatic has three distinct categories of mushroom supplements, namely; (Think) for boosting your focus and increasing productivity, (Defend) offering daily nutrition, boosting immunity, and gut health, (Chill) offering the best relaxation properties. Also, in your shops, you will find supplements categorized into coffees, Caicos, and proteins.

Four Sigmatic originates from Finland, a land where people have enjoyed the benefits of mushrooms like lion’s mane and chaga for many centuries. The most profound mushroom supplements under Four Sigmatic are Mushroom Blend Mix, plant-based protein powders, and mushroom coffees. Notably, all Four Sigmatic supplements are USDA Organic certified, thereby eliminating all your doubts while purchasing the product. Four Sigmatic is a reputable household name to look out for when purchasing mushroom supplements.

Real Mushrooms


Real Mushroom is one of the few family-owned mushroom farms and supplement manufacturers that have lasted in the business for over 40 years. Real Mushroom has been in the mushroom supplement business longer than many companies, meaning you can count on their expertise any day.

The most popular Real Mushroom supplements are formulated in the form of powders and capsules. There are various capsules and powders to choose from, including cordyceps, reishi, turkey tail, tremella, and chaga mushroom products. Also, there are other mushroom concoctions such as Mushroom Hot Chocolate Mix and 5 Defenders.

The company is based in the productive region of Vancouver and guarantees the best quality mushroom supplements you will find in the online space. Real Mushrooms offer a great deal of value for money, as their products range from $25 to $35.



MUD\WTR is a coffee substitute that induces the benefits of organic ingredients to generate satisfaction for all its customers. The company’s goals lie in causing the energy-boosting effects of coffee while maintaining caffeine levels at minimum levels. Every dose of MUD/WTR contains chai, cacao, sea salt, turmeric, and cinnamon blend synergized with the benefits of mushroom ingredients such as reishi, chaga, cordyceps, and lion’s mane.

MUD/WTR is the perfect choice for anyone seeking to boost their morning energy levels in the morning without the jitters associated with high caffeine blood levels. Each dosage comprises 1/7 the caffeine present in coffee, while the rest of the ingredients are USDA Organic certified. A MUD\WTR Ritual Starter Kit (with a free frother and 30 servings of mud) sells at $40, inclusive of shipping.

Mushroom Defense


Mushroom Defense supplement reduces body famishment and shields the body against related cognitive conditions. Reports from the manufacturer indicate that Mushroom Defense boosts energy levels, defends the body against viral and bacterial attacks, reduces memory loss and other perceived benefits missing from other mushroom supplements.

Additionally, Mushroom Defense comes with a 67-day money-back guarantee. Mushroom Defense offers a wide variety of mushrooms such as shiitake, cordyceps, turkey tail, and lion’s mane. Every dosage contains a blend of 10 mushrooms mixed with a ratio of 80% fruit bodies and 20% mycelium. Mushroom Defense continues to be one of the leading mushroom supplements across various online sellers.

Organixx 7M+


Organixx 7M+ is an immune-boosting fermented mushroom formula that offers the synergetic effect of seven immune-building mushroom potents. The most common organic ingredients include lion’s mane, cordyceps, turkey tail, shiitake, chaga, and reishi mushrooms. The manufacturer guarantees that all mushrooms are properly fermented to ensure optimum nutrition.

Organixx 7M+ contains kelp extract, an ingredient that is missing in other mushroom formulas. The ingredient purportedly boosts liver function. By consistently taking a dose of 7M+ daily, you are bound to enjoy the benefits of mushroom extracts, antioxidants, and beta-glucans.

Pure Essence MyPure Lion’s Mane


Lion’s mane mushroom supplement is another household name in the supplement space. The name of the supplement betrays it all. With every dose of Lion’s mane you take, you get a wholesome amount of lion’s mane. According to Pure Essence, the lion’s mane is one of the best supplements with cognitive benefits and boosts the immune system. The supplement claims to reduce memory loss, recover lost memories, cognizance, and improve overall mental health.

The Pure Essence My Pure Lion’s Mane is quite popular among many customers as the supplement is 100% organic and is made from pure lion’s mane mushrooms. Each dosage contains 20-40% beta-glucans blended from pure mushroom fruiting bodies. The resultant supplement is an entirely organic mushroom supplement that is free from any additives.

The Genius Brand Genius Mushrooms


The Genius Brand Genius Mushroom is a nourishing blend that contains reishi, lion’s mane, and cordyceps mushrooms as the main ingredients. The synergistic action of the different mushrooms boosts energy levels, restores memory, boosts cognitive abilities, and maintains liver health.

Genius Mushroom sells at a relatively low price and is priced at $22 per bottle. Also, the product has numerous product reviews that ascertain its credibility as a cutting-edge mushroom supplement. Genius Mushroom supplement is available in different blends depending on the perceived benefits. You can choose cordyceps for high energy levels, reishi for overall body health, and lion’s mane for cognitive development.

Mushroom Revival


Mushroom Revival claims that mushrooms are the future of all supplements, and people ought to look out for these supplements as they have many health benefits. The most profound formulas in Mushroom Revival include; Cordyceps Energy Tincture, Lion’s Mane Focus Tincture, the Mushroom Mix Daily 10 Tincture, and the Reishi Calm Tincture. You can never go wrong with Mushroom Revival, as it has a wide range of mushroom blends to choose from.

Earth Nutri Performance Energy + Focus


Earth Nutri Performance Energy + Focus claims to improve the overall physical and cognitive health using a specific blend of organic mushrooms and other cutting-edge ingredients. The most profound elements are alpha-GPC, organic mushroom powder, citicoline, and theacrine. The supplement offers the benefits of both mushrooms and nootropics, blended into one wholesome supplement.

Energy+Focus consists of a blend of various mushrooms that have been tried, tested, and found to reduce famishment, maintain high energy levels for a long time. The most popular blends include reishi, cordyceps, shiitake, lion’s mane, turkey tail, and king trumpet. Every serving of Energy+Focus contains 2000mg of mushrooms. Enjoy the serving by mixing one portion of the supplement with water and enjoy your drink.



FreshCap offers a wide array of mushroom supplements, with the most popular blends formulated as mushroom coffees and powders to give you the best morning and evening relaxation, as well as other perceived benefits.

According to the manufacturer, the FreshCap supplement boosts your energy levels, immunity, and cognitive benefits. There are also different mushroom supplements to choose from, with Lion’s Mane Capsules and Turkey Tail supplements, which both retail at $35 per bottle. Also, FreshCap is available in multiple mushroom blends popularly known as THRIVE, a blend that contains six different mushrooms and Unwind, Focus, and Mushroom Coffee.

You will notice that FreshCap comes in one of the most attractive packages, and do not let the package deceive you; the contents inside the package are even better. The mushroom supplement is one of the best formulas you will find across various online platforms. It is also recommendable to purchase different mushroom supplements and mix them to suit your preference.



VidaCap is another company that offers multiple mushroom supplements to suit your different needs at any time of the day. Ideally, you can choose from supplements such as Sleep, Reishi, and the widely accepted Lion’s Mane supplement. The prices are pretty affordable, with every bottle selling at $24, notwithstanding the quality remains top-notch.

You can rest assured as all the mushroom ingredients present in VidaCap are sourced from greenhouses in China and Russia. Soon after the mushrooms are harvested, they are dried, graded, and ground. Also, a third-party tasting body is called into action to ensure that only the highest quality supplements make it to your shelves, as well as minimize the risk of packaging harmful products. VidaCap ensures that you receive maximum value for money, and the company promises to maintain a high level of confidence for all its customers.



Shroomy comes in a unique formulation as it is one of the two mushroom supplements in our esteemed list that comes in the form of a gummy. The supplement is sold as a nootropic mushroom formula that poses maximum cognitive benefits. A daily dose sells at $1, and you can choose from cordyceps, lion’s mane, and reishi.

For scholars and researchers who crave that extra mental energy, lion’s mane gummies ensure that you are highly energized to read some extra hours. For those looking to improve their immunity, the reishi mushroom blend is ideal. On the other hand, cordyceps increase metabolic activity through increasing ATP production. Shroomy ensures you enjoy the benefits of a mushroom supplement at the convenience of a gummy.

Ceremony Mushrooms


Ceremony Mushrooms is known for its best-selling mushroom tinctures, with each targeting certain perceived benefits. The tinctures include Sleep Tincture, Stress Relief Tincture, Digestion Tincture, and Mushroom Blend Tincture. Every dosage is a healthy combination of adaptogenic blends, herbs, and mushrooms.

Just like any other mushroom tinctures, Ceremony Mushroom tinctures are priced relatively higher than different mushroom formulas. The majority of online sellers sell the supplement at $45 per bottle.

GundryMD Mushroom Vitality


Mushroom Vitality is the brainchild of California-based company, GundryMD, and with its high quality, the product sells relatively high. According to the manufacturer, Mushroom Vitality boosts immunity as well as energy levels.

Mushroom Vitality is one of the few mushroom formulas that are formulated in the form of liquid tinctures. To make a dose of the supplement, mix 4ml of the supplement with water, and you will be ready to go.

Developed by Dr. Gundry, Mushroom Vitality comes in chaga mushroom, reishi mushroom fruiting body, and Coriolus mycelium fruiting bodies.

Circadian Wellness


The formula in Circadian Wellness supplement uses proprietary technology to mix high-quality ingredients and come up with supplements that offer specific benefits on targeted needs, including sleep, pain, cognition, energy, libido, among others.

Circadian Wellness is based on the assumption that an aligned circadian rhythm is essential for a healthy body, mind, and soul. What’s more, the ‘Quicksome’ technology used in developing the supplement ensures you get more excellent absorption at low dosages.

MycoPhyto Complex


Manufactured by Advanced Bionutritionals by Dr. Isaac Eliaz, the MycoPhyto Complex supplement combines six proven mushroom extracts in each capsule. The ingredients include cordyceps, Polyporus, turkey tail, reishi, royal Agaricus, and maitake mushroom extracts.

Every pair of capsule formulas administers 1.28g of the ingredients above to optimize the health-supporting benefits. An extra dose of 50mg is also available.

Goldmine Supershroom Powder


Goldmine Supershroom Powder is one of the most recognizable names in the supplements industry. According to the manufacturers, Goldmine Supershroom Powder effectively strengthens the body’s immune system using herbs, antioxidants, and anti-inflammatory mushroom ingredients.

A serving of 0.5 to 1 teaspoon of Goldmine Supershroom Powder up to three times a day administers enough plant magic for health benefits. Magic Mushroom


Although is marketed as a “magic” mushroom, they are not magical. However, the supplement’s magical benefits are understandably why the formula is referred to as a magical blend.

Just like many other supplements in our list, contains all-natural ingredients that are USDA Organic certified. The brand ensures that each batch is tested and proven by third-party labs throughout production to ensure safety and efficiency.

Brain Forza Organic Lion’s Mushroom


Brain Forza Organic Lion’s Mushroom uses lab-grown mushrooms to produce high-quality and more powerful supplements than wild-grown mushrooms. According to the company, the supplement is 2-6 times stronger than other ordinary mushroom supplements because its formulation contains 1g of polysaccharides per serving.

Additionally, the formula is considered to be among the purest form and most potent mushroom supplements available in the market today. It has been verified to be free of contaminants such as pesticides, herbicides, and heavy metals.

VitaPost Immune Support


VitaPost Immune Support contains a blend of plant-based plant extracts, including mushroom extract, that help the health of the body in several ways. The active ingredients in the formula include green tea, quercetin, antioxidants, and herbal extracts that are important for the body’s immunity in several unique ways.

At $14 per bottle, VitaPost Immune Support is perhaps one of the most reasonably-priced mushroom supplements in the market today.



Spore is a mushroom supplement that purports to eliminate brain fog, enhance daily cognitive function, and boost mental focus, among other benefits. This supplement offers proven ingredients to increase cognitive effects for anyone looking for a natural energy booster, anti-aging formula, libido booster, and neuroprotective supplement.

Vital Plan Adaptogen Recovery


Vital Plan Adaptogen is a mushroom formulation created by Dr. Bill Rawls to strengthen the immune system and make the body more resilient. The formula contains ingredients such as cordyceps extract, Rehmannia extract, Chinese Skullcap Extract, and reishi mushroom extra to help the body respond to cognitive and physical stress.

Although pricier than other mushroom supplements in our list, Vita Plan Adaptogen Recovery contains 180 capsules, making it comparable to the other products on the list.

The Drug Store Adaptogenic Mushrooms


The Drug Store uses popular ingredients that target the body’s immunity, cognition, and overall health. According to the manufacturers, Drug Store is safe and effective and comes at a competitive price compared to similar products.

Botany Cordyceps Militaris Extract


The Cordyceps Militaris Extract formula is manufactured by Botany Biosciences, a highly acclaimed supplements company. The brand claims this supplement provides the same benefits one might experience from cordyceps, including treating chronic bronchitis, kidney complications, male sexual health, heart complications, unexplained weight loss, opium addiction, and moderating cholesterol levels.

Each product comes accurately labeled with a lab reports access code for quality and transparency assurance. The manufacturer also claims to slightly surplus the labeled amount to account for loss to container adhesion.

Each container has 30g (1.06oz) of the formula, which should provide a month’s dosage. The manufacturer recommends taking 500mg doses twice a day. The powder form supplement can be consumed by adding to foods or beverages.

The company also offers free worldwide shipping, with insurance on the products.

Plant People WonderDay


WonderDay is a gummy form product of the Plant People supplements brand. The formula provides ten mushroom types to boost energy, stabilize mood, improve gut health, and relieve stress. They include maitake, shiitake, lion’s mane, white button, royal sun, wood ear, turkey tail, chaga, reishi, and cordyceps. It also comprises a wild raspberry ingredient that provides a good flavor. One jar of the formula consists of 60 gummies and 250 mg of mushroom extract per serving.

It draws its health benefits from the ingredients’ effects, such as relieving anxiety, improving the cardiovascular system, strengthening the immune system, boosting energy, mental focus, and exercise performance. It may also support gut health and cellular health. Other ingredients in the formula include sodium citrate, vegetable oil, and purple carrot juice.

5 Mushrooms Reserve Blend


5 Mushrooms Reserve Blend is a product of the Hippie Farms supplements company based in the US. The formula consists of some of the most popular mushroom types in the supplements industry. They include lion’s mane, chaga, reishi, turkey tail, and cordyceps.

The formula is specially designed to target brain health and improve cognitive function, nerve function, and memory. According to the manufacturer, it may also stabilize mood and counteract aging symptoms. The company also claims to put it under repeated tests to eliminate any harmful substances and maintain the formula as a vegan-safe supplement.

5 Mushrooms Reserve Blend is designed for adults; hence, it might be unsafe for children. Besides the $30 initial price, you can also enjoy a $3 cut on every bottle for subscribing to a regular shipment program.



MindHoney was created by DOSE Nomadic Nutrition, a renowned supplements company founded in 2019 by Austin Platt. Although the formula mainly comprises nootropics, it is designed to approach health rejuvenation from three main perspectives. It improves mood stability, mental health, and general body health.

It comprises some of the most beneficial mushroom types, such as lion’s mane, reishi, cordyceps, and chaga. Its mind-enhancing blend includes ingredients such as NeuroFactor, DMAE Bitartrate, N-Acetyl L-Tyrosine, and CoffeeBerry. It also consists of Ashwagandha and American Ginseng in its adaptogenic blend.

According to the manufacturer, the supplement can reduce stress and eliminate end-day crashes. The company also claims to have tested the product for increasing brain-derived neurotrophic factor (BDNF). Each bottle of the supplement contains 60 capsules. The manufacturer recommends a daily dosage of 2 tablets.

Brain Boost


Brain Boost was formulated by Dr. Rawls, according to Vita Plan, its parent company. The formula consists of a nootropic blend that aims to improve brain health and cognitive functions.

The formula comprises ginkgo leaf extract, bacopa, cat’s claw bark, ashwagandha leaf, root extract, and lion’s mane. Other ingredients include plant-based magnesium stearate, Oryza sativa, and plant cellulose. According to its official website, the supplement consists of clinically recommended doses of herbs. It has also been subject to independent third-party lab tests for potency and purity.

The manufacturer claims the supplement can improve memory, mental clarity, focus, microbiome, natural energy, immunity, and mood stability. You can also enjoy a 10% discount on subscribing to the auto shipping program, which allows you to cancel orders by sending an email just before deliveries.

The Ranking Process for the Best Medicinal Mushroom Supplements

Finding legit products in the supplements market is challenging, especially since the FDA is not authorized to approve even the best. Whether good or poor, all manufacturers will associate their products with the best benefits, whether true or not. But we based our research on the following metrics to determine those that deliver.

Tested and Proven Ingredients

Despite the vast types of mushrooms in the world, only a few are fit for supplements. Based on the analysis of scientific studies, we only selected products that consisted of science-backed ingredients.

Clinically Effective Dosages

A mushroom supplement with the right ingredients but the wrong dosage might be ineffective with harmful elements. It might pose a higher risk of suffering adverse side effects in case of an overdose. Scammers will either eliminate such information or hide it under proprietary labels. In this ranking, we only considered manufacturers that provided accurate dosage information, close to the recommended.

Scientifically Backed by Trials or Tests

When dealing with human health, consumable products must be subjected to repeated testing for safety and effectiveness. However, not all supplements brands test their products. Therefore, the lack of testing automatically became a red flag in our ranking. We gave companies with test results the top recommendations.

Manufacturer Reputation

While manufacturers may claim all the possible benefits, their reputation will always reveal the truth. Customers will always praise a good brand and express disappointments if there are any. Public reputation is reliable since it’s built upon the views of people who have spent their money when trying a company’s products.

Production Methods

We were also keen to observe which parts of a plant these brands claim to source their ingredients from. Different parts of a plant have other properties, which means that, for example, the root of a plant can have medicinal value while its leaves lack. We ensured that the mentioned parts are scientifically proven to be beneficial as mentioned.

Extraction Methods

The extraction method used to withdraw the necessary medicinal components may affect the effectiveness and safety. Depending on the nature of the mushroom and a company’s resources, different extraction methods such as hot water and alcohol may be used. However, some solvents may react undesirably with other ingredients in the formula to cause side effects.

Medical Advisory Board

Today, anybody with sufficient funding may start a supplements company and base its formulae on anecdotal evidence. Some of the formulators lack any substantial background in the wellness industry. But some companies comprise teams that may include certified specialists, helping to ensure the products are safe and effective. We preferred companies with advisory boards, as their decisions are well thought out.

Advertised Benefits

Some of the best mushroom supplements in the market offer substantial health benefits. However, some manufacturers go overboard with their advertisements, claiming to reverse some conditions permanently. As much as the formula might be exceptional, being a supplement, it cannot perform as much as medication. We eliminated manufacturers with such false claims.

Refund Policy

Unlike medication, supplements perform differently to different bodies. But even medicine acts to varying extents due to body tolerances. Having lesser effects, supplements might not cause any substantial effects to some individuals, who might feel like their money is wasted. Still, offering a money-back guarantee is one way for the manufacturer to show confidence in their formula.

Medicinal Mushrooms Side Effects

Typically, mushroom supplements do not cause any significant side effects when consumed by healthy individuals in the recommended dosages.

However, a slight increase in doses might lead to mild symptoms of nausea and digestive complications. The most significant side effects might result from the consumption of magic mushrooms. This type of mushroom contains psilocybin, a component associated with psychoactive effects such as hallucinations.

Nonetheless, you should be safe from any harmful side effects if you take legal and tested mushroom formula. Their approval means that they lack any health hazards, perhaps besides some allergy triggers.

If you are unsure of whether a mushroom supplement is safe for you, it is always recommended to consult a doctor. This also applies to individuals with existing medical conditions.

The History of Medicinal Mushrooms and Mushroom Supplements

Despite their long history, mushrooms have only started trending as remedies to various problems, including health issues. However, they have been used to solve many human problems long before ancient times.

Otzi, also known as the iceman, lived between 3400 and 3100 BC. His body was discovered frozen in the Otztal Alps in September 1991. Upon his discovery, researchers found two species of mushroom in his pocket. According to studies, one mushroom species aided in the fight against infections and parasites while the other helped start fires.

Mushrooms were also a critical part of ancient Egyptians. According to hieroglyphics, ancient Egyptian formal writings, mushrooms were consumed by supremes such as pharaohs to promote health and longevity.

Mushrooms were also part of Roman and Greek traditions during their reign. Dioscorides, Seneca, and Pliny, notable titles in Roman times, all studied and wrote much about mushrooms as remedies.

Several studies have also found the Chinese to have been studying mushrooms as long back as 100 BCE. According to the data, the then Chinese medicine practitioners had found mushrooms to affect various health conditioners such as respiratory complications and cancer. Some renowned mushroom remedies today were inspired by ancient Chinese.

The current interest in mushrooms has only lasted about a century. One of the most significant discoveries was made in 1928 when Alexander Fleming discovered penicillin, a fungus component. Until today, penicillin has saved an estimated 200 million lives.

Fleming’s discovery inspired more research into mushrooms, which has led to the discovery of antibacterials and antiviral effects in other species of mushrooms.

Currently, studies on various mushroom types and components such as psilocybin are still in progress.

Scientific Evidence for Medicinal Mushrooms and Mushroom Supplements

Approximately, there are over 1.5 million fungi species that occupy a significant percentage of the planet’s total biomass. However, only a few of them have medicinal benefits.


Cordyceps is one of the most popular mushrooms among supplement brands. The Chinese and Tibetan traditionally used the mushroom as a remedy to various health conditions. Purportedly, it provides benefits such as improving athletic performance, respiratory functions, stamina, and sexual health. A 2020 study suggested the component can improve exercise ability in older individuals. During the study, among 20 healthy individuals in their 50s and 70s, some were subjected to 333 mg of cordyceps dosage three times daily, while others were given placebos over 12 weeks. At the end of the study, researchers concluded that those who consumed cordyceps had increased exercise performance, endurance, and metabolic rates.


Reishi, a mushroom type that wildly grows on hardwood trees and stumps, was also a traditional medicine in the Chinese community. Its highly acclaimed benefits include increased energy, immunity, cognitive functions, and improving sleep quality.

It can also reduce anxiety. A 2018 study that targeted the constituent compounds in the mushroom unveiled that some had a calming effect while others had antioxidant, immunity-increasing, and tumor-inhibiting properties.

According to some studies, this type of mushroom potentially holds some anti-allergic properties, hence its use in counteracting allergic reactions.


Maitake is also a popular supplements ingredient that purportedly supports a variety of conditions, including strengthening the immune system, moderating blood sugar levels, and relieving digestive complications.

According to studies, this type of mushroom contains beta-glucans, which are polysaccharides that positively affect various body conditions, including inflammation, blood sugar, and weight. Other studies also suggest the possibility of maitake strengthening the immune system during chemotherapy.


Shiitake is the second most abundant mushroom in the world, only second to the typical button mushroom. It is mainly used in Asian cuisine, although new evidence suggests its effectiveness as a health remedy. The mushroom has potential benefits to cholesterol levels, skin health, and liver health. Some Japanese scientists created an extremely purified shiitake extract to be used as a remedy for gastric cancer.

Turkey Tail

Scientifically known as Coriolus Versicolor, this type of mushroom has vibrant color and bitter taste, hence not suitable for consumption. It also has a tougher texture compared to other types.

Turkey tail contains polysaccharide-Krestin, a compound that has immune-boosting properties. It is due to this compound that the mushroom has been legalized as an anti-cancer medication in Japan.


As much as this is the most unpleasant-looking mushroom on this list, it is also the most potent source of antioxidants, which come with numerous health benefits. Chaga helps to inhibit inflammation and eliminate free radicals, which might tamper with cellular health. Its antioxidants also help to recover from digestive complications and to kill various viruses in the body.

Lion’s Mane

Despite its popularity among supplement manufacturers, the lion’s mane is another bizarre-looking mushroom that purportedly stimulates the increase of nerve growth factor (NGF). According to several studies, the ingredient has potential benefits to brain neurons and the immune system. However, its uses are not limited to these. It may also relieve mild depression and anxiety symptoms. Other studies suggest it could help with diabetic symptoms and dementia.

While more scientists endeavor into mushroom research, we remain in a continuous learning process whose ends seem promising with lots of potential discoveries. But for now, these are some of the most significant findings.

FAQs about Medicinal Mushrooms and Mushroom Supplements

Q: How do mushroom supplements work?

A: Mushroom supplements comprise a variety of ingredients that have different unique properties and chemical compositions. They might consist of antioxidants, vitamins, and phytochemicals that affect specific health conditions. The formulas are designed in a way that the properties of the different ingredients supplement each other.

Q: How do I take mushroom supplements?

A: Most mushroom supplements come in capsules, although many exist in tinctures, powder, and gummies. Some are taken as a whole as they grow. Depending on the supplement form, you can either consume it by ingesting, sublingually, or topically. Powder forms may be added to fluids or edibles.

Q: Are mushroom supplements legal?

A: Some mushroom products are legalized, while some have limited approval. The legal ones are Generally Recognized As Safe (GRAS) by the FDA. GRAS mushrooms include turkey tail and lion’s mane, while the regulated ones include psilocybin mushrooms.

Q: Can I buy medicinal mushroom supplements?

A: Yes. Unlike some medications that have to be recommended by a certified physician, medical mushrooms are purchasable through various e-commerce sites such as Amazon, but mostly their official sites.

Q: When is the best time to take mushrooms?

A: Being supplements, medicinal mushrooms are mostly consumable anytime, especially during meal times. However, different manufacturers may provide further instructions depending on their formulations.

Q: What’s the best dose of the mushroom extract?

A: Most mushroom supplements have a recommended dosage of 1-2 capsules per day. However, you shouldn’t assume this for every product as they have varying potencies. Dosage may also be affected by the mushroom species and additional ingredients’ concentration.

Q: What are the side effects of mushroom supplements?

A: Typically, mushroom supplements are considered safe. However, their extra ingredients and production process may lead to a different reaction that might result in side effects. The most common side effects concern digestive discomforts. However, most supplements do not cause any side effects when taken in the proper doses by healthy individuals.

Q: What are magic mushrooms?

A: Magic mushrooms contain dangerous compounds such as psilocybin. They are not legalized for use in supplements.

Q: What is psilocybin?

A: Psilocybin is a component found in magic mushrooms that convert into psilocin upon ingestion.

Q: Is psilocybin legal?

A: The potential health risks of consuming psilocybin have been classified under Schedule I illicit drugs in the US since the 70s. Therefore, medical products manufacturers may not include it in their products, although some are pushing for its legalization.

Q: How does psilocybin work?

A: Currently, no studies have unveiled how the component induces psychedelic effects, hallucinations, and other brain alterations. However, some suggest that the psychedelic components change the brain by stimulating neuron growth and branching between dendrites.

Q: Are mushrooms addictive?

A: Mushroom supplements are not associated with the same part of the brain as other drugs. They also lack any habit-forming components.

Q: Are mushrooms a fruit or vegetable?

A: Mushrooms are neither fruits nor vegetables, but rather fungi.

Q: Where do mushrooms come from?

A: China and India are the most popular mushroom sources among supplement brands. However, even the US grows some mushroom types, especially shiitake and maitake mushrooms.

Q: Where do mushrooms grow in the United States?

A: Mushrooms are found all over the states, although Pennsylvania produces more than half the total amount.

Q: What are the health benefits of mushrooms?

A: Some of the most common reasons people resort to mushroom supplementation are detoxification, immunity, and improving their general health, although different mushroom products are designed to address various health conditions.

Q: Are mushrooms a superfood?

A: Studies show that mushrooms can make good superfoods as they are low in fats and calories. They are also rich in nutrients and antioxidants.

Q: What is Psilocybe?

A: Psilocybe is a genus of gilled mushrooms with over 150 species. Nearly all of these mushrooms contain the psychedelic compounds such as psilocybin, baeocystin, and psilocin.

Q: What are the best mushrooms for health benefits?

A: Some health-beneficial mushrooms include chaga, reishi, lion’s mane, shiitake, maitake, oyster, turkey tail, and cordyceps.

The Best Medicinal Mushroom Supplements in 2021 Final Word

Today, mushrooms have broader uses than when they were only seen as a source of food. With the reinvention of their medicinal uses, the industry will likely attract more researchers and funding, possibly leading to significant discoveries.

With their mind-altering properties, magic mushrooms have drawn much interest from researchers who think they might have some fantastic uses behind the psychoactive effects.

Nonetheless, notwithstanding the many benefits mushroom supplements manufacturers might claim, always keep in mind that supplements cannot be as effective as medication.

ALSO READ: Best Liver Supplements on the Market in 2021 (Review Rankings)

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Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.

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