When mentioning vital body organs, it is hard to skip past the liver. This may be because of the numerous roles it plays to support normal body functioning. Some of these roles include regulating body temperature and breaking down fats and proteins. It is also responsible for detoxifying the body. Hence, it is advisable to always take care of it, as failure may lead to recurrent health problems.
An excellent way of taking care of your liver is by ingesting liver supplements. These supplements target vital parts of the liver to improve its general well-being.
Contrary to popular opinion, not everybody is conversant with this topic. That is why we decided to develop a detailed article that explains various aspects of the world of liver supplements.
The Best Liver Supplements in 2021
We want to begin by discussing the top liver supplements one can take for good liver health.
We know it is challenging to scour through tons of internet materials to find the best. That is why our experts took up the challenge for you. They studied numerous supplements using company records and reviews. In the end, they developed a list that included the following products:
- Organifi Liver Reset
- 1MD Liver MD
- Live Conscious LiverWell
- Amy Myers MD Liver Support
- Zenith Labs Zenith Detox
- Gundry MD Complete Liver Support
- Advanced Bionutritionals Advanced Liver Support
- PureHealth Research Liver Health Formula
- ActivatedYou Morning Complete
- VitaPost Liver Support Plus
- Phytage Labs Urgent Liver 911
Naming them is one thing and having an in-depth understanding of the products is another. That is why in this next segment, we will discuss each of these supplements in detail. This will help you comprehend all of the essential aspects of the products to make an informed choice.
Organifi Liver Reset
Liver Reset rose to take our top position because of several reasons. First, the supplement is cheap as it costs around $28 for one month supply. Secondly and most importantly, it is said to have various liver-boosting ingredients. It is these components that help in keeping the liver sanctified. The supplement contains milk thistle, dandelion root, artichoke leaf extract, and Triphala.
Each of these ingredients is organic and is incorporated in the proper proportions. The company does this so that the product provides the most benefits.
1MD Liver MD
Next on our list, we have 1MD Liver MD. The spectacular product from 1MD is perhaps one of the most accessible supplements in the world. This is because it is distributed on many eCommerce platforms. Some of these sites include; Amazon, eBay, and Walmart. In other words, the supplement is a simple click away.
1MD is the first supplement on our list to contain clinically proven ingredients. It has milk thistle extract, 800mg and 100mg of NAC and ALA, respectively. It also has liver-loving minerals, vitamin E, and selenium.
Other than liver supplements, 1MD shelves stock other beneficial products. You can visit their site to explore mushrooms, digestive, heart, and many other supplements. Cost: $45
Live Conscious LiverWell
This supplement is said to support liver health using natural ingredients. It contains thistle milk extract and ALA (Alpha Lipoic Acid). These two components are known to come together to help the liver regulate blood sugar. Live Conscious Liverwell also has NAC (N-acetyl cysteine), a good antioxidant.
The recommended dose of the supplement is at least two capsules a day. By taking this quantity, you will be helping the liver detoxify. Doing so is also said to support liver cells.
The supplement is quite affordable compared to its rivals. For only $26, you can get yourself a bottle of Live Conscious LiverWell.
Amy Myers MD Liver Support
Coming from one of the top supplement manufacturers, it is no surprise Liver Support made it to the list.
Liver Support features a unique blend of ingredients that are said to help detoxify the liver. Alpha-lipoic acid is one of the ingredients contained in this fantastic product. Through it, the supplement is claimed to have the ability to destroy free radicals in the body.
Amy Myers MD Liver Support also has a reasonable concentration of NAC. The product’s NAC is believed to act as glutathione’s precursor. In the world of medicine, glutathione’s precursors reduce oxidative stress in the liver.
For an adequate dose, the company recommends you take two capsules per day. Cost: $35
Zenith Labs Zenith Detox
At times, we all need that one formula to solve our long list of health issues. If a good number of your health issues are liver-related, this might just be the savior you have been looking for.
Zenith Detox is a liver supplement formulated by a certified doctor. The product has been praised by many as it is said to have numerous health benefits.
All of these advantages can largely be attributed to the product’s ingredients. Zenith Detox contains several components similar to other liver supplements. Just like they are said to be effective in those products, so are they here. In essence, this product is believed to eliminate free radicals in the system. By doing so, it supports healthy liver functions.
In this supplement, you will also find unique ingredients that are not used in any other products. An excellent example is Schisandra berry extract. According to scientists, the component lowers markers of liver damage in the body.
Gundry MD Complete Liver Support
Next on our list, we have Gundry MD’s Complete Liver Support. The product is famous for its distinct combination of beneficial ingredients. It contains 1000mg of orange peel extracts, milk thistle, and dandelion. Orange peels extracts, for instance, are purported to improve the functioning of the liver. This is according to reports of research conducted by various scientists.
Complete Liver Support is also known to improve the absorption of nutrients. Furthermore, experts claim that the product helps the liver mount defense against toxins. This explains why Gundry MD markets the product as a deadly Swiss Army Knife to your liver. Cost: $20
Advanced Bionutritionals Advanced Liver Support
Advanced Bionutritionals is an American firm that manufactures a wide range of supplements. One of these supplements is Advanced Liver Support. This fantastic product contains an array of ingredients known to support liver functions. Some of these components include; ALA, Milk thistle, selenium, and NAC.
The company recommends adults take four capsules of Advanced Liver Support daily. Doing so is believed to load their bodies with active ingredients that protect the liver against oxidative stress. It is also claimed to support your brain functions. Cost: $40
PureHealth Research Liver Health Formula
Liver Health is a neuropathic formulated formula that is said to give you “unlimited energy.”
The supplement contains three key components, each serving a specific role. These ingredients are; alfalfa, beet, and ginger. Alfalfa is claimed to rejuvenate your liver cells membrane. Scientists also believe that it lowers cholesterols. Beet, on the other hand, contains antioxidants, vitamin B6, and iron. This combination is said to reduce inflammations. Of course, we cannot forget about the benefits of ginger. Its inclusion is purported to protect the liver against alcohol and other toxins.
Despite being a magnificent supplement, it is a bit pricey, retailing at $49. However, it is undoubtedly worth every penny.
ActivatedYou Morning Complete
Morning Complete is advertised as a nourishing formula believed to help your entire body. This is because it contains superfoods, fibers, probiotics, prebiotics, and other helpful ingredients.
Just so that we are together, a probiotic is a combination of beneficial active bacteria and yeast. Sources of probiotics include; yogurt, pickled vegetables, and kombucha. Increasing the number of probiotics in your body is known to be helpful to your liver.
In contrast, prebiotics are officially described as indigestible foods that stimulate bacterial growth. They work by providing a medium for digestive bacteria to thrive on. They, too, may boost liver functions and improve the general wellness of the body.
The company also describes this wellness formula as a potent drink that works against oxidants. That is why taking the supplement is said to reduce blood sugar levels. It is also claimed to support several body functions, of course including the liver.
As a multipurpose formula, the supplement carries a hefty price tag. It is sold for $79 a bottle, around four times higher than our cheapest supplement. All in all, if its benefits are what you are looking for, feel free to try it out.
VitaPost Liver Support Plus
The liver is regarded as one of the human body’s “donkeys.” The name is derived from the fact that the liver works extremely hard just to keep everything going. According to VitaPost, this is enough reason for one to give it special care and treatment.
Now the good thing with VitaPost is they did not just offer a vague proposition. The firm sat down and came up with a real solution. The company developed an affordable liver formula known as Liver Support Plus.
Their formula contains vital ingredients like artichoke extract and celery seed. Studies show that celery seeds lower blood cholesterol, thereby protecting your liver. On the flip side, artichoke extracts have in the past shown promises of liver nourishment.
Besides the ingredients named above, Liver Support Plus contains other liver-healthy constituents. We have ingredients like milk thistle, yarrow, and chicory root. All of these constituents are critical in maintaining good liver health. Chicory root, for instance, has been claimed to protect the liver from toxins. Cost: $27.95
Phytage Labs Urgent Liver 911
Urgent Liver 911 is a product designed to work against liver toxins. It also claimed to repair and flush out fats clogging in the liver. All of this is possible because of its excellent combination of ingredients.
According to Phytage Labs, their raw materials are sourced from different locations worldwide. Thus, they have distinct properties that will keep your liver in good shape. Some of these ingredients are vitamins, curcumin, silymarin, dandelion root, and yarrow.
The company also states that its ingredients are distilled for potency and purity. This may explain the supplement’s hefty price of $70 a bottle. To find the supplement, visit Amazon or any major eCommerce store.
Bonus: The Non Alcoholic Fatty Liver Disease (NAFLD) Solution
More than 50 million adults worldwide are affected by chronic liver diseases. Some of the common causes tied to liver diseases are alcoholism, poor diet, and viral infections. Out of the 50 million, probably half of them could have prevented the onset of these diseases. That is if they knew how to go about it.
To ensure that you do not become a part of these statistics, here is a guide to help you better your liver health.
According to experts, implementing a proper diet and a healthy lifestyle is suitable for your liver. One such expert is Julissa Clay.
Julissa, a liver specialist, says that there are several natural ways to achieve optimum liver health. Each of these methods is detailed in Blue Heron Health Market’s e-books.
In one of their books- The Non Alcoholic Fatty Liver Disease Solution, Julissa expounds on several treatment programs that could turn your life around. The solutions help your body melt away excess fats in the liver, thus boosting your health.
Finally, the total cost of the NAFD solution is only $49. Looking at the price tag, this might be one of the cheapest ways of improving your liver’s health.
How We Ranked The Best Liver Supplements in 2021
Using their experience and skills, our editors came up with criteria to rank the products. These ranking factors are listed below;
Ingredients with Proven Benefits
The ingredients in liver supplements are the ones that contain active components that affect the liver. That is why many people in the industry pay close attention to them, and we were no different. In our rankings, we were looking for scientifically backed ingredients in a supplement.
If a supplement had components that had proven benefits, it had a higher chance of being listed. If not, it was immediately disqualified.
Generally, doses play an essential role in the efficacy of a supplement. Some companies use low doses that provide little to no effects. On the other side, other firms recommend just the right amount that will keep your liver healthy.
Those companies that advised users to take realistic and correct doses drew our attention quickly.
From our list, we have several doctor-formulated supplements. To our editors, this was a direct entry onto the list of best liver supplements. This is because the formulators tabled their medical experience thus, creating the best products.
Benefits of the Product
Supplement manufacturers have mastered the art of exploiting customers. They do this by falsifying their products’ benefits. They use terms like ”cure the liver completely and remove all wastes” to air out false claims. These are unrealistic benefits.
We were wary of companies that did not give the correct information about their products’ advantages. Conversely, firms that highlighted truthful benefits of their products stood a chance to make it to the list.
The Reputation of the Manufacturing Company
We all know how nowadays, trust is a scarce commodity. Fortunately, in our ranking process, we met manufacturers with well-established reputations. We trusted such companies because they had a clear motive of offering the best and clean supplements, just like they have been doing in the past.
Price and Value of the Supplements
If we factor in the current economic situation, the affordability of a liver supplement is essential. Hence why we included supplements that were affordable and offered the best value.
What Does Science Say about Liver Supplements?
For almost two thousand years, plant extracts have been used to treat diseases. Today, scientists are expounding on this concept of medicinal plants. They are even going further to investigate their effectiveness when included in supplements.
Their research has provided better explanations on how liver supplements work. Experts have even narrowed them down to their specific active components. They have also validated the use of minerals, vitamins, and some plant extracts to help the liver.
Here is more information on what science says about the ingredients in liver supplements.
Milk thistle is a small shrubby plant with purple flowers native to Europe. According to experts, the plant has huge potential to boost liver functions and improve general well-being.
For over two millennia, this shrub has been used to treat liver problems. This explains why many liver supplement makers include it in their products.
Silymarin is a key ingredient found in milk thistle. It is said to help regenerate liver tissues. It has also been linked to anti-inflammation effects and the protection of liver cells.
In a review study conducted in 2017, scientists found out that silymarin affected markers of liver issues. This meant that silymarin played a crucial part in decelerating the progression of liver disease.
It is no secret that milk thistle is a widely used component in this industry. However, studies have confirmed that it is less effective than other ingredients. In essence, a person who ingests milk thistle is expected to have very slight changes in the liver.
Artichoke Leaf Extracts
Historians believe artichoke originated in Sicilian Island or somewhere in Africa, probably Tunisia. From the 1500s, the plant has been an essential part of Roman medicine. This is mainly due to its antioxidant properties that help to protect the liver.
The history of artichoke’s medicinal benefits is what prompted experts to carry out studies. The aim was mainly to ascertain its effectiveness.
In one study, scientists saw that artichoke could reduce liver damage markers. In essence, it helped patients with non-alcoholic fatty liver diseases.
Dandelion root is a familiar figure in the liver supplements industry. This is so even though only a few studies back its benefits. Nonetheless, we must not undermine dandelion’s benefits to human health.
A 2006 article published by the Journal of Ethnopharmacology showed that dandelion could work as an anti-oxidative. Researchers also unlocked its anti-carcinogenic properties and other benefits the plant offers to the liver.
Zinc is said to have massive effects on a person’s liver. When present, it stimulates proper hormone regulation and functioning of the liver. Zinc deficiency, in contrast, may manifest itself in liver cirrhosis and liver degeneration.
A study to examine the relationship between zinc and the liver was conducted in 2012. In the end, it was found that zinc protects the liver against oxidations. Furthermore, the research showed that zinc could reverse the effects of liver cirrhosis.
This is considered one of the world’s oldest medicinal roots. It is usually harvested from licorice, a plant native to Asia. Licorice plants can also be found in southwestern parts of warm Mediterranean regions.
Nowadays, the root is used in candies, drinks, and deserts, and it is beneficial to the body. Licorice root is alleged to treat acne and sore throat. However, much information about the plant’s benefit to the liver has not been revealed.
Scientists once carried out research involving 379 people with chronic hepatitis C. The experts found out that licorice could tame the disease. The patients showed signs of a significant reduction of hepatitis symptoms.
A different group of scientists also conducted a study on the root. In this case, the test subjects were rats. The study’s results showed that the root reduced alcohol-induced inflammation.
Although licorice root is a beneficial substance, you should take it with care. Extracts from licorice roots contain a high concentration of glycyrrhetinic acid. The acid is known to cause hypokalemia, sodium retention, and hypertension.
Turmeric, also known as Curcuma, has an active ingredient known as curcumin. The compound is believed to support liver health.
In one study, scientists found out that taking a small dose of turmeric daily reduced the levels of ALT and AST. Alanine Transaminase (abbreviated as ALT) is an enzyme that is usually found in the liver. Its role is to help in converting proteins into energy for the liver cells. Aspartate transaminase (AST) is also an enzyme, just like ALT. However, AST is used in amino acid metabolism.
In a standard scenario, both of these enzymes are supposed to be at low levels. If they are found to be high, that indicates a problem, specifically in the liver. Now that is why the findings of the scientists were integral in keeping the liver healthy. This is because when turmeric controls AST and ALT levels, the liver is left to thrive.
Yellow Dock Roots
Yellow dock is a herb whose leaves and buds are customarily used to create crunchy salads. Its roots and fruits, on the other hand, possess medicinal components.
In liver supplements, this plant is rarely mentioned as an ingredient. However, some people claim it has been used to reduce inflammations and detoxify the blood for centuries.
Now let us examine it from a scientific angle. Yellow dock has active ingredients known as anthraquinones. These ingredients are believed to support liver health.
Generally, taking yellow dock roots is said to increase the frequency of urination. This is otherwise termed as having diuretic effects. Diuresis (diuretic effects) helps the body get rid of salts, thus cleansing the blood.
Taking yellow dock roots also stimulates peristalsis and increases the production of mucus. This cumulatively flushes out wastes from the digestive system.
Beetroot, Alpha-Lipoic Acid, Molybdenum, Choline, Selenium, and Ginger
These ingredients are said to help the liver in one way or another. Ginger, for instance, is known to protect the liver against cellular damage. Molybdenum, another crucial component, is said to activate enzymes that remove toxins from the blood. This relieves the liver from its primary function of detoxification. As a result, it is kept healthy.
Signs and Symptoms of Liver Problems
A person with liver issues may exhibit/experience:
- Body weakness/fatigue
- Weight loss which in most cases is unintentional
- Releasing Grey stool
- Discomfort or stiffness on the lower part of the rib cage and just above the abdomen
- Lack of appetite
- If the disease progresses, the above signs and symptoms will graduate to;
- Confusion and cognitive problems
- Personality and mood swings
- Memory loss
- Yellowing of the skin and eyes scientifically known as jaundice
Best Ways of Supporting Liver Health
Taking care of your liver is a lifelong process. It involves putting in place measures that ensure your liver is never in jeopardy. These measures are as follows;
Reduce Your Fat Intake
After consuming a fatty meal, the fat is absorbed through the blood and deposited in the liver. This leads to non-alcoholic fatty liver disease (abbreviated as NAFLD). NAFLD is simply a set of conditions linked to liver damage.
All in all, by reducing fat intake, you will find that a small amount of fat is deposited in the liver. As a result, you can prevent NAFLD.
Invest in Good Supplements
Supplements provide your liver with vitamins, minerals, and many other nutrients. Some products are even said to prevent conditions like inflammation. By doing so, they help improve the liver’s health. These supplements are also known to remove toxins from the blood. The removal of such harmful substances prevents the liver from being poisoned.
Drink Alcohol Moderately
Alcohol is also said to destroy the liver by depositing fat droplets in its cells (steatosis). This usually happens when one indulges in binge drinking. Binge drinking is excessive consumption of alcohol within a short time. In layman’s language, it means taking more than four bottles of alcoholic drinks in less than 2 hours.
In a nutshell, drinking moderately will help protect your liver from steatosis, thereby promoting good health.
Do not Smoke
Smoking introduces tobacco toxins to your blood. When the liver filters these toxins, it becomes inflamed. This might be the onset of liver cirrhosis or even cancer.
Protect Yourself from Chemical Toxins
When working on a farm or plant, your body may absorb poisonous substances from the chemicals used. During biological detoxification, the liver filters such chemicals from the blood. Once they have been filtered, they accumulate inside the organ. This then leads to diseases.
That is why you need to reduce your exposure to poisons/chemicals.
Do Away With Hard Drugs
Hard drugs like cocaine and heroin cause the liver to inflate and damage. That is why it is advisable to avoid them at all costs to protect your liver.
Do Not Overuse Medications
Hepatotoxicity is a liver disease caused by overusing over-the-counter drugs.
When your liver detoxifies the blood, it filters out drugs. The processed bits are then flushed through the urine and bile. In some cases, the drugs may not all be flushed out. These remaining particles could then cause inflammations.
Cancer, antianxiety, and acetaminophen drugs are highly likely to cause liver diseases. This is according to a report by the FDA. Therefore, ensure that you always follow the doctor’s prescription to the letter.
FAQs about Liver Health Supplements
Q: By definition, what is a liver supplement?
A: These are plant extracts and natural products that come in the form of powders or capsules. They are usually claimed to detoxify the liver and rejuvenate its cells.
Q: What is a liver?
A: This is a cone-shaped internal organ located below the ribcage on your right side. It is responsible for detoxification and blood sugar regulation. The liver also stores glucose to power your body during lean times.
Q: What are some of the roles of liver supplements?
A: They play a noble role in liver detoxification, protection, and optimization of its functions. Some supplements even work against inflammation and support the immune system.
Q: How can I take supplements?
A: Most liver supplements are available in the form of capsules and powders. One can take the pills by simply swallowing them with water or a drink. On the other hand, powders are mixed with beverages, soups, or even teas and consumed.
Q: What are the best liver supplements?
A: You can choose any supplement from the list above. Each product was carefully selected and analyzed to ensure that we give you nothing but the best.
Q: What are the roles of a liver?
A: The liver is known to perform many functions like breaking down fats and producing blood-clotting chemicals. It is also responsible for the activation of enzymes.
Q: What are the causes of liver damage?
A: Liver damage is caused mainly by poor lifestyle decisions. Too much drinking, smoking, and taking hard drugs are excellent examples of such habits. Overusing prescription drugs is also known to cause liver diseases. In other cases, scientists have tied viral infections, specifically hepatitis, to liver damage.
Q: Is liver disease genetically inherited?
A: Though you can’t inherit liver diseases like cirrhosis, genes play a vital role in determining the organ’s health. NCBI states that you can inherit conditions like hemochromatosis and cystic fibrosis. All of which are known to be detrimental to the liver’s health.
Q: What are other causes of liver damage other than alcohol?
A: Most people assume that all liver patients were, at one time, prominent drinkers. What they are forgetting is that many other things can cause liver disease. One of these things is overusing prescription drugs. A person’s lifestyle and exposure to toxins are also factors that can cause liver damage.
Q: What are some of the signs of liver damage and diseases?
A: The common telling sign of liver damage is jaundice characterized by yellowing skin and the eyes. Additionally, people with liver problems are said to experience mood swings and depression. These signs are usually accompanied by fatigue, poor appetite, and constipation.
Q: Can you reverse liver damage?
A: The liver has the ability to self-repair, no matter the extent of damage it is exposed to. So yes, you can reverse liver damage if you implement the right strategies.
Q: What are the symptoms of liver disease?
A: Early on, one may experience symptoms like lack of motivation, itching, and fatigue. As the situation worsens, you may start passing dark urine and showing signs of jaundice. In some cases, you may even have memory and cognitive issues.
Q: What can one do to cleanse their liver?
A: Taking up a healthy diet to detoxify your body is an excellent way of cleaning the liver. Exercising and taking supplements have also been known to cleanse damaged livers.
Q: How can you know that you have liver disease?
A: Seeing a doctor and having them carry out tests is the surest way to know whether or not you have liver disease.
Q: Is it advisable for one to take a liver supplement?
A: Generally, supplements have been known to have a positive effect on the user’s liver. However, always consult your medical practitioner beforehand to advise you if it is okay to take one. You should do so, especially if you are currently under medication.
Q: Is hepatitis classified as a liver disease?
A: There are five known types of hepatitis, and all of them are categorized as liver diseases.
Hepatitis B and C are said to contribute to more than 80% of liver cancer cases. This is according to an article published by the Hepatitis B Foundation.
Q: What is liver cirrhosis?
A: Liver cirrhosis is damage or scarring of the liver caused by liver diseases and toxins. It usually occurs after several failed attempts of the liver to repair itself.
Q: What is the primary cause of liver damage in the USA?
A: In the USA, most cases of chronic liver disease are attributed to hepatitis. Alcohol and overusing medications have also been listed as leading causes.
Q: Is the liver the largest body organ?
A: The skin is the largest body organ. However, when we are talking about internal organs, the liver is by far the largest.
Q: What do doctors use to test for liver diseases?
A: Doctors use a group of blood examinations scientifically known as liver function tests. These tests look for signs of inflammation and alcohol damage.
Q: Am I supposed to detox regularly?
A: Detoxifying your body is regarded as a healthy habit. For that reason, the body, including the liver, will always benefit from it. However, this does not mean that regular detoxification will directly improve liver health, as there is no scientific research backing it.
Q: What can you eat to keep your liver healthy?
A: Doctors recommend eating a balanced diet to keep your liver in good shape. You are also advised to include vegetables and fruits in your meals. Other medical experts urge people to take foods rich in fibers and drink more water.
Q: Are liver supplements effective?
A: Liver supplements are said to contain vital ingredients which support liver health. Some of these ingredients include; milk thistle, turmeric, and zinc.
Q: Is it safe to take liver supplements?
A: It is okay to take liver supplements as long as you follow the prescribed dose.
Q: Are supplements harmful to the liver?
A: Liver supplements are beneficial to the liver and are not likely to cause any damage to it. Kindly note that these benefits come in only when you go by the recommended dosages.
Q: What is a fatty liver?
A: This is a medical condition characterized by large amounts of fat being deposited/building up in the cells of one’s liver. It is generally caused by lifestyle, poor health habits, and genetics.
Q: What is NAFLD?
A: NAFLD is an abbreviation for Non-alcoholic fatty liver disease. This is a collection of both minor and major liver-related disorders.
The Best Liver Supplements in 2021 Conclusion
Taking liver supplements is one of the surest ways of keeping the organ in good condition. This is because supplements are known to hamper inflammation and protect the liver from toxins. They are also said to prevent cell damage. Even so, you need to know that taking care of your liver involves more than just ingesting supplements. You are also supposed to reduce fat intake, do away with hard drugs, and stop smoking tobacco. Furthermore, lifestyle changes and eating well-balanced diets are also said to work wonders. Try any of the liver supplements above, and you’ll be glad you did.
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Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.