Best Heart Supplements for Healthy Cardiovascular Support

It’s hard to deny the importance of your heart. Heart disease kills millions of people annually, making it the most dangerous health condition in the world. Even more disastrously, heart disease is complicated to detect, and many people don’t realize that they have a debilitating heart health condition until it’s too late to address it. This has led to some medical professionals calling heart disease ‘the silent killer.’

But our health problems in the heart don’t end with heart disease. People might also develop high blood pressure and several additional issues that arise from it. Men and women with high blood pressure may experience organ failure, diabetes, and other severe conditions. High blood pressure may seem uncommon, but labeling this heart condition rare would be a mistake. Some studies have shown that over half of the United States suffers from high blood pressure.

Dealing with heart health requires a combination of responsive and preventative treatments. Some experts argue that preventive treatment is the best way to keep your heart healthy and strong. After all, waiting until you develop severe heart conditions to strengthen your heart may mean you’ve waited far too long.

Heart health also relates closely to other health issues in the body. For example, people with high blood pressure are far more likely to suffer from high cholesterol or kidney failure. The list of conditions influenced by poor heart health is long, and we don’t have time to get into these health problems in this guide. People worldwide are at risk of developing severe, potentially life-threatening heart problems. The purpose of this guide is to introduce readers to a variety of nontraditional health care treatments used to improve heart health.

You don’t necessarily need to go through a round of troubling traditional medicines to properly maintain and improve cardiovascular health. Supplements for heart health have gained popularity in the past decade – and with good reason. While supplementation is never a good substitute for medical advice and treatment, some evidence suggests that regular cardiovascular supplements can effectively address heart problems before they become serious. Additionally, healthy people that use cardiovascular supplements might be able to lower their risk of developing a heart condition in the future.

For this guide, we’ve put together a list of the best cardiovascular supplements of 2022. We’ll also cover everything you need to know about heart health and supplements before we get into the actual rankings. Keep reading to learn the most important things consumers should understand about buying and using heart health supplements.

Why Use a Cardiovascular Supplement?

The answer to this question should seem pretty straightforward, but you might be surprised by the number of people who ask us why they should use a cardiovascular supplement. The answer is a bit different than most people might assume. Who do you think should use a heart health supplement? If you’d respond by saying that the primary audience is people who currently have heart conditions, then you’re mistaken.

Generally, we recommend that the best demographic for cardiovascular supplements are people who have not yet had a severe heart health problem. These folks might have a family history of heart problems or have never even heard of a heart attack in their lineage. Regardless, these people are perfect for heart health supplements because the primary function of most heart pills is preventative. A heart supplement’s goal is to improve the heart’s health slowly. More importantly, many heart health supplements are specially formulated to help protect the heart against developing conditions like high blood pressure, high cholesterol, or even heart failure.

If you’re assuming that one gender or age group is the primary target for heart health supplements, you’re also mistaken. Men may, on average, be more likely to suffer from heart disease, but that doesn’t mean that women are safe from the silent killer. Both men and women can suffer from damage to the heart as they age, and both men and women stand to benefit from strategically taking cardiovascular support supplements to lower their risk of heart disease, attack, or related issues.

As we age, our likelihood of developing heart disease increases significantly. This doesn’t mean young people can’t suffer a heart attack or die due to heart disease. Thousands of people in their 20s succumb to one or more of the heart illnesses we’ve mentioned. For this reason, cardiovascular supplements are usually recommended to people of all ages. Older Americans should take cardiovascular supplements because their risk of developing heart disease is higher, and young Americans should take these formulas to get a solid head start on strengthening the heart and maximizing overall health and wellness.

Only one group of people should be cautious about taking heart health supplements. People suffering from a heart condition or taking heart medications should consult their doctor before using any new heart supplement. While most of the supplements on our ranked list are free of significant side effects, these alternative medications can react negatively to some treatment plans. Always speak to your doctor before trying a new heart supplement.

How We Ranked The Best Cardiovascular Supplements

You should never take supplement recommendations based solely on faith. This section will give readers a comprehensive look at the factors we used to rank our favorite cardiovascular supplements in 2022.

Ranking all of our top supplement picks undoubtedly was not easy. As we mentioned in the introduction to our guide, millions of people have started looking into cardiovascular supplements to improve their health as they age. This explosion in popularity has been an acute oversaturation in the supplement market. While this competition means that many great supplements have been introduced to the market, it also means that scams are prevalent.

We can’t include all of the qualities we evaluated in this guide. Still, the list below should give readers a solid introduction to some of the most important factors when determining the best heart health supplements to use in 2022.

Here are the components we considered when ranking our top heart health supplements:

Scientific Support

We’ll cover this element of rankings in our next section. Consumers should know that the scientific support for a supplement depends on several factors. It’s hard to find verified, peer-reviewed studies on heart health formulas, but we worked to figure out which supplements are backed by scientific research. Some formulas on our list are backed by extensive study, while one or two medical experts have supported others. We looked for the most scientifically supported supplements to make up our heart health supplement list.

Honest Advertisements

As we mentioned above, many shady companies on the supplement market have pushed their supplements by using impossible or unlikely claims. This can have disastrous results when dealing with something as serious as heart health. We disregarded any supplement that claims to reverse the effects of a heart attack, improve heart health overnight, or improve multiple organs at one time. We like to rank only supplements offering genuine and scientifically supported medical benefits.

Company Reputation

Company reputation is not essential to every supplement consumer, but we consider the public rep of a company to be a critical component of our ranking system. We included a few supplements from new companies on our list. Still, we tend to stray toward organizations with at least some significant public support when deciding which supplements to add to our rankings.


We always like to draw an important distinction between price and value in this section. Many supplements are priced low but still offer very little value. Other formulas have a high cost but still, provide high value. We looked to include a combination of high and low-priced formulas on our list, but we only really ranked supplements that offered substantial value for their cost.


This may be the most critical factor in our ranking system. We give ingredient lists quite a bit of weight when we compare supplements against one another, and the reason shouldn’t be hard to understand. After all, even the most scientifically supported supplement is worthless if its ingredients don’t provide substantial benefits to consumers.

As we said, this list doesn’t begin to cover the extensive and exhaustive nature of the process we use to rank heart health supplements. We take our rankings very seriously because we know how seriously consumers take the health of their hearts. Still, anyone conducting their independent research should use the five above factors to help them guide their search for the best heart health supplements.

Scientific Evidence Behind Cardiovascular Supplements

Scientific evidence for many heart health supplements on our list is limited. This doesn’t mean that the formulas are ineffective or unsupported. The main reason why this is the case is that scientific studies rarely focus on commercial dietary supplements. There are a few reasons why this is the case, but we won’t bore you with an essay on the politics of medical research today. Instead, let’s take a closer look at how and when medical experts generally study a dietary heart supplement.

Most studies on heart health supplements focus on the ingredients contained within these formulas. For example, consider a hypothetical supplement containing mint. While the supplement itself may not be administered in research trials to test its efficiency, there may exist studies linking mint to heart health benefits. We’d therefore use this research to make claims about the effectiveness of the supplement in question, which contains significant amounts of mint.

We prefer to purchase supplements that use many scientifically supported heart health ingredients. Minerals, vitamins, and fatty acids might help improve heart health, and an excellent cardiovascular supplement should include a healthy dosage.

One common ingredient used in heart health supplements is CoQ10. This formula has been demonstrated to provide antioxidant effects in multiple studies. One study from 2016 found that the supplement ingredient can improve heart health at a cellular level by increasing the production of heart-boosting compounds within the mitochondria. In one critical landmark study on CoQ10, researchers found that CoQ10 might help to lower the odds of developing heart failure in men and women.

Some supplements on our list are primarily composed of Omega-3 fatty acids. According to Harvard Medical School, this supplement ingredient can improve heart health by promoting the production of crucial heart health acids in the body.

The story is the same for many supplement ingredients referenced in today’s ranked list. Ingredients like Vitamins C and E, L-arginine, resveratrol, prebiotics, and other vital ingredients have been supported by a decade of scientific research. Using a combination of these ingredients may significantly improve heart health over time in some consumers. As always, we recommend you take our scientific analysis with a grain of salt. After all, your research should be the ultimate guide you use to determine the supplements you choose to put into your body.

In summary, scientific research demonstrates a clear link between heart health and many vital ingredients used in supplements within the heart health sector. Using the formulas on our list regularly may give consumers better heart function and a lower risk of severe heart conditions.

Side Effects of Using Cardiovascular Supplements

For most healthy adults, taking heart health supplements will not result in severe or significant side effects. Several individuals yearly suffer from non-serious or minor side effects while using heart health supplements. However, these people generally suffer side effects because they misuse the supplements they purchase. For example, some people might take too much of a supplement, which can have minor side effects.

Additionally, some men and women suffer side effects from heart health supplements because they’re already taking medications provided by their doctors. If you’re currently taking multiple medications for your heart, consider speaking to your doctor before taking any new supplement.

We also recommend carefully researching and reading the dosage requirements listed on each supplement you try. Taking too much of a supplement can spell trouble, especially if the supplement is interacting negatively with something in your diet or medical treatment routine. People suffering from any medical condition should strongly consider reading and rereading the directions before taking any supplement.

None of this is meant to scare you. Most people who use heart health supplements will never suffer serious side effects. This is one of the significant upsides to using supplements instead of relying on traditional medical treatments to improve heart health. Because the ingredients in the formulas on our list are all natural and unprocessed, the chance of developing adverse reactions to them is meager.

Some consumers might struggle with allergies to the ingredients in supplements on this list. While allergies to these key ingredients are exceedingly rare, they might exist. People with allergies should always ensure their dietary supplements don’t contain allergens. The supplements on this list are no exception. Please also note that we did not include a list of allergens on the supplement reviews on this list.

Take supplements safely and follow your doctor’s recommendations to ensure you won’t experience side effects. After all, the last thing you want when you take heart health supplements is to end up in the hospital!

The Best Cardiovascular Supplements of 2022

If you’re bored with our background information, this is the moment you’ve been waiting for. It’s time to talk about our picks for the best cardiovascular supplements of 2022:

  • PureXanthin
  • PhysioTru Physio Omega
  • BiOptimizers Magnesium Breakthrough
  • Cardio Clear 7
  • Advanced CardioRX
  • Genius Heart
  • Gundry MD Heart Defense
  • Amy Myers MD CardioGuard
  • Qunol Ultra CoQ10
  • Oweli Omega-3 Fish Oil
  • Primal Harvest Omega-3
  • Prociva
  • BioTrust OmegaKrill
  • Advanced Bionutritionals Advanced Blood Pressure Formula
  • CellXRenewal
  • CardioFit MD
  • PhytAge Labs Blood Pressure 911
  • PhytAge Labs Heart Beat 911

This list was painstakingly compiled using the qualities discussed in our “How we Ranked” section. These formulas have been ranked on our list for their company reputation, ingredient lists, scientific support, and more. We recommend that consumers looking to improve their heart health and decrease their odds of developing a heart condition consider trying some supplements on the list below.



We were impressed by this formula’s efforts to tackle heart problems from multiple angles. In addition to addressing heart disease and boosting overall heart wellness, this formula might help consumers improve their joints’ health. As the heart and joints increase in function, the creators of PureXanthin claim that consumers might also experience improved skin health, endurance, energy, and brain function.

These claims may feel a bit exaggerated, but the ingredient lists in PureXanthin may significantly improve overall health in multiple ways. The main ingredient in this supplement is astaxanthin, which can decrease blood pressure and cholesterol levels. Two capsules per day of PureXanthin can provide all of these benefits.

PhysioTru Physio Omega


As the supplement’s name suggests, this formula is being marketed as a way to fight against the risk of heart attacks preemptively. The formula purposely avoids fish oil, which its creators call ‘rancid.’ There’s some truth to this claim; fish oil has a distinctive smell and might be overused in some of the most popular supplements in the world.

To avoid fish oil, PhysioTru instead employs several different omega-3 fatty acids. Scientists have long known these compounds to help improve the heart’s health, decrease blood pressure and cholesterol levels, and more. The wide range of benefits associated with PhysioTru Physio Omega is impressive.

BiOptimizers Magnesium Breakthrough


It shouldn’t be hard to figure out one of the main ingredients in this formula. After all, the name makes it clear that magnesium is a core component of the supplement. This formula uses magnesium in high dosages and malate, orotate, bisglycinate, citrate, and more. The long list of ingredients with proven medical track records makes this newcomer to the supplement market a force to be reckoned with.

The evidence suggests magnesium can increase nervous system function, leading to better immune health, heart strength, and even stronger bones. We also appreciated the price of this formula; it’s quite a bit cheaper than some of the supplements on our list. At only $35 for a month’s supply, BiOptimizers Magnesium Breakthrough is one of the most cost-effective supplements on the market.

Cardio Clear 7


The chemical CoQ10, which we outlined earlier in this guide, is the star of this supplement. Using a combination of CoQ10, shilajit, and disodium salt, this formula is used to improve the overall health of the heart and veins. This formula contains only the three above mentioned ingredients, differentiating it from many other supplements on our list. This formula makes itself distinct from many others on the health supplement market, many of which pump users full of several mystery ingredients as part of a shady ‘proprietary blend.’

The disodium salt in the Cardio Clear 7 formula is also one of the most intriguing supplement ingredients. It increases the power of the mitochondria, and some studies suggest that it might also decrease inflammation.

Advanced CardioRX


The core base of this supplement’s patented formula is a collection of different fatty acids. These ingredients may help improve the heart’s overall health in several ways. One of the most significant advantages to purchasing Advanced CardioRX is that each purchase comes with several additional ‘freebies.’ Advanced CardioRX works closely with each consumer to help them steer their way to improved heart function and overall wellness.

The benefits of buying Advanced CardioRX include free online coaching, fitness nutrition guides, a risk assessment tool, an entire library of health information, and several apps to help track and improve your heart health over time.

Genius Heart


For consumers who want to improve their blood pressure, Genius Heart is a fascinating choice. This formula is inexpensive; each month’s supply sells for only $45. Grape seed extract appears in this formula, which is unique for supplements on our list. The natural supplement benefits heart function, cholesterol levels, and vein pressure.

We also appreciate the reputation of the brand that Genius brings. Genius Heart is one of several supplements in the Genius line, which is respected among consumers for its low prices and high-quality supplements. At $45 per month, Genius Heart provides quite a bit of value to consumers. These capsules are also veggie capsules, which makes them vegan-friendly. In addition to grape seed extract, this formula includes major CoQ10 and Vitamin K2 dosages.

Gundry MD Heart Defense


Like Genius Heart, Gundry MD Heart Defense comes from a manufacturer with significant clout in the supplement market. Gundry MD is known as one of the foremost supplement companies in the industry, and thousands of consumers will attest to the company’s attention to detail and the scientific formulation behind each supplement formula. This particular formula is easy to digest; it can be mixed into any drink/shake and drank once daily. The chocolate flavor has won high consumer praise for being easy to take and enjoy.

Flaxseed powder, prebiotics, and coffee are vital ingredients in this formula. Coincidentally, these ingredients have been scientifically proven to provide a few key benefits, especially to the heart and energy levels.

Amy Myers MD CardioGuard

Amy Myers MD CardioGuard IMAGE

CardioGuard is one of the rare supplements in this industry that a genuine medical professional has formulated. Amy Myers is a medical expert with a degree from a licensed medical school. She created this formula to help people improve the health of their hearts while also improving immune health and lowering cholesterol. If the backing of an actual medical doctor isn’t enough to support this formula, a quick look at its ingredients should do the trick.

Amy Myers MD CardioGuard employs a combination of ingredients; magnesium, L-carnitine, B Vitamins, and various probiotics. This group of elements is well-known for boosting heart health, and consumers may find that CardioGuard promotes several additional benefits outside of the heart and veins.

Qunol Ultra CoQ10


Care to take a guess at what ingredient is featured in this formula? CoQ10 is one of the most common supplement ingredients in the heart health sector, and Qunol Ultra CoQ10 is one of the best formulas regarding CoQ10 content. The formula’s manufacturer explains that this formula is designed to increase absorption in the body by 300%. Remember: the body doesn’t naturally absorb every ingredient in the supplements it ingests. A higher absorption rate means that the formula’s components are more likely to provide the desired effects.

We loved researching this formula because of the high degree of consumer reviews it offers. The formula has been purchased and reviewed over 45,000 times on Amazon, making it one of the most popular supplements we were able to rate. This formula has won an average rating of 4.7 stars – which is superb for the number of verified users it offers.

Oweli Omega-3 Fish Oil


Weight loss, immune health, joint strength, and several other benefits are associated with this formula. Fish oil is one of its key ingredients, but the formula also includes multiple other Omega-3 fish oil ingredients. At 2,400 mg of pure fish oil, the formula has some of the most potent fish oil extracts on this list. This is excellent news for people who have already researched the extensive medical benefits of fish oil and omega-3 acids.

Oweli is not the most respected company on this list; they’re relatively new. But the low price and high potency of this formula suggest that the company is working to become one of the preeminent companies targeting the heart health market. This formula also benefits people trying to lose weight, making it one of the best values we saw on our list.

Primal Harvest Omega-3


In addition to being made in the United States inside an FDA-approved manufacturing plant, Primal Harvest Omega-3 offers a long list of benefits from its clinically proven supplement ingredients. The formula blends both EPA and DHA, two primary fatty acids known for their extensive benefits to heart and vein health. The formula is packaged in softgels that are easy to digest by happy consumers.

In addition to the EPA and DHA doses, each serving of this formula includes arachidonic acid and marine lipid oil concentrate, two supplement ingredients capable of increasing cholesterol health. DHA is revered among supplement researchers for its ability to improve skin, eyes, and brain health.



This formula works by directly targeting cells in the heart. As any scientist will tell you, your heart is a muscle. Working it out regularly helps it to keep healthy and strong. Cardio exercises, such as running or climbing stairs, are one big way to increase heart health. However, a supplement like Prociva could help if you need a little extra boost. This supplement uses arjuna, hibiscus, folic acid, magnesium, and vitamin D.

The combination of all-natural ingredients in Prociva makes it an ideal candidate supplement for consumers who want to protect their heart against damage, decrease fat levels in the blood, and decrease their overall chance of developing heart disease or a stroke.

BioTrust OmegaKrill


If you’ve spent even a minute within the supplement market, you should know who BioTrust is. This company has produced various supplements that provide consumers with multiple benefits. For the OmegaKrill supplement, the main advantage has to do with overall heart health. According to some consumers, krill oil is better than fish oil. Over time, taking too much fish oil might force the body to accumulate toxins. Krill is also a more sustainable commodity, which is good news for our pro-environment readers.

This formula contains a hefty dose of krill oil, which can provide the same benefits as fish oil while also helping to improve energy levels, cognition, and heart health over time. The key to using this supplement is consistent dosages. At a price of only $34, BioTrust comes out swinging with one of their most popular cardiovascular supplements.

Advanced Bionutritionals Advanced Blood Pressure Formula


Advanced Bionutritionals is another major company trying its hand at heart and blood pressure supplements. This is one of the most cost-effective formulas on our list; $30 gets you a month-long supply of Advanced Bionutritionals Advanced Blood Pressure Formula. This supplement is composed of several all-natural ingredients, several of which are relatively rare to find within the heart health supplement industry.

Peony root Bark, Gardenia Fruit, Salvia Root, and several other ingredients make up the foundation of the Advanced Blood Pressure Formula of Advanced Bionutritionals. These ingredients have been used for centuries in Ancient Chinese medicine, which is quite an endorsement for consumers who are fans of traditional medicines.



While cardiovascular supplements are meant to be used by nearly anyone, CellXRenewal is the first supplement on our list to market its formula primarily to aging consumers. As we age, we become more likely to suffer from heart conditions, including heart attacks, strokes, and heart disease. CellXRenewal uses ingredients like Ecklonia Cava to promote antioxidant and anti-inflammatory properties, providing extensive benefits to the heart.

Some people also use CellXRenewal to promote sexual health, making it an extremely versatile supplement. This formula sells for about $69 per month, making it one of the most expensive supplements on our list. Still, the wide variety of benefits it provides to aging consumers may make it well worth the cost.

CardioFit MD


CardioFit MD is another formula designed by a licensed medical professional. This formula also comes in a convenient powder, making it easy to digest throughout the day in the form of water, a shake, or any other liquid. The formula might not be as packed full of minerals as some of the capsule pills on our list, but that doesn’t mean it’s less potent. CardioFit MD is composed of probiotics, prebiotics, minerals, fiber, and vitamins to promote heart health, lower blood pressure, and higher nitric oxide production.

Reviews for this newish supplement are overwhelmingly positive, and some consumers praise its delicious flavor and high potency.

Blood Pressure 911


This is one more company that needs no introduction. This supplement manufacturer has been producing supplements in the market for quite some time, and its reputation speaks for itself. Vitamin B12, garlic, olive, hibiscus, green tea extract, and several additional ingredients are combined to create Blood Pressure 911. Primary benefits include higher energy levels, lower cholesterol, optimized blood sugar, and more.

Depending on your size and desired results, you can take one or two capsules of Blood Pressure 911 daily. The formula’s all-natural ingredients are easy to digest, and consumers report that Blood Pressure 911 helped them to control blood pressure and cholesterol levels better.

PhytAge Labs Heart Beat 911


PhytAge Labs rounds out our list of the best cardiovascular supplements of 2022. This company has been around for nearly a decade, and its reputation may be one of the best. PhytAge Labs markets its supplements primarily to aging consumers, which is great to see in a heart supplement. In addition to benefits to overall heart health, PhytAge Labs promotes higher blood flow, healthier blood pressure, and more.

This product is produced at home in the United States and uses all-natural ingredients. The formula is packaged in an easy-to-use softgel capsule. At $69.95 for a one-month supply, PhytAge Labs charges a bit of a premium for its solid brand name. Still, the company’s reputation may justify an additional cost for some consumers.

Frequently Asked Questions About Cardiovascular Supplements

This section will cover a few of the most commonly asked questions about heart health supplements.

Q: How do you use cardiovascular supplements?

A: Some cardiovascular supplements are packaged in softgel capsules. To use these supplements, just take one or two daily pills, depending on the directions on your package. Two supplements on our list are packaged as powders, which can be mixed into liquids and consumed once daily.

Q: What are the side effects of cardiovascular supplements?

A: Most people experience no side effects when using cardiovascular supplements. If you’re currently suffering from a medical condition or taking medical conditions, some supplements may cause minor side effects. Be sure to consult your doctor before using a new heart supplement.

Q: What are the benefits of cardiovascular supplements?

A: Cardiovascular supplements can help people improve heart health in several ways. Most supplements boost overall heart strength and wellness, while others focus on lowering cholesterol and regulating blood pressure.

The Best Cardiovascular Supplements of 2022 Final Thoughts

Today, we’ve walked readers through some of the best supplements in the heart health market. The heart is your most important organ, and taking care of it is a lifetime commitment. In addition to regular exercise, a healthy diet, and a lifestyle centered around wellness, supplementation can be a good tool for people looking to keep their hearts happy and healthy.

Always do your research before using a new heart health supplement, but feel free to reference our guide for some tips on how to spot the best heart health cardiovascular supplements on the market.


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